College football odds, picks, top predictions, best bets for Week 8: Proven simulation loves Clemson, Iowa

SportsLine's advanced computer model has revealed its top Week 8 college football picks

By CBS Sports Staff

Oct 22, 2022 at 11:05 am ET • 3 min read

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Nick Saban hasn't lost back-to-back regular season games since the 2007 season. After dropping a game at Tennessee last weekend, Saban and the No. 6 Alabama Crimson Tide will look to keep that streak alive as they host No. 24 Mississippi State at 7 p.m. ET on Saturday. The latest Week 8 college football odds from Caesars Sportsbook list the Tide at -21 in that one. Elsewhere in the SEC West, LSU is -1 against No. 7 Ole Miss in the 3:30 p.m. ET SEC on CBS game.

Other contenders in action include No. 5 Clemson (-14) against No. 14 Syracuse in a battle of undefeated ACC squads. And the only top-10 matchup on the Week 8 college football schedule comes in the Pac-12 where No. 10 Oregon is -7 against No. 9 UCLA. Before locking in any Week 8 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 8 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 8

One of the college picks the model is high on in Week 8: No. 5 Clemson (-14) cruises to a blowout win against No. 14 Syracuse on Saturday in a noon ET battle of undefeated ACC squads. The Tigers have won four straight against the Orange, and they've scored 41 or more points in two of the last three meetings against Syracuse.

Quarterback DJ Uiagalelei has been playing well in recent weeks, especially against ACC opponents. The junior QB has thrown three or more touchdown passes in three of his last four outings, and he's scored three rushing TDs in his last three games. In addition, the Tigers are 7-1 against the spread in their last eight games in conference play, which is one reason why the model expects Clemson to cover the spread almost 60% of the time.

Another one of the model's top college football picks: Iowa (+29.5) has no problem keeping it within the four-score spread when it travels to take on No. 2 Ohio State at noon ET. The Hawkeyes rank third nationally in scoring defense, giving up just 9.8 points per game. They've done very little on offense, but SportsLine's model is banking on that elite defense keeping this one within the number.

Ohio State leads the nation with 48.8 points per game, but the model projects that they don't get to 40 in this one. Iowa scores a couple times in the simulations, keeping this margin around 20 points. Iowa covers nearly 70% of the time and the total sneaks over 50 with a couple points to spare. See which other teams the model likes here.

How to make college football picks for Week 8

The model has also made the call on who wins and covers in every other FBS matchup in Week 8, and it says a top-20 favorite will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-20 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.